Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2

Extracellular signal-regulated kinase is an MAPK that is most closely associated with cell proliferation, and the MEK/ERK signaling pathway is implicated in various human cancers. Although epidermal growth factor receptor, KRAS, and BRAF are considered major targets for colon cancer treatment, the p...

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Vydáno v:Cancer Sci
Hlavní autoři: Fujishita, Teruaki, Kajino-Sakamoto, Rie, Kojima, Yasushi, Taketo, Makoto Mark, Aoki, Masahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471789/
https://ncbi.nlm.nih.gov/pubmed/25855137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12670
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