Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity

We determined which metabolic pathways are activated by hypoxia-inducible factor 1–mediated (HIF-1–mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...

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Publicat a:JCI Insight
Autors principals: Singh, Charandeep, Hoppe, George, Tran, Vincent, McCollum, Leah, Bolok, Youstina, Song, Weilin, Sharma, Amit, Brunengraber, Henri, Sears, Jonathan E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675544/
https://ncbi.nlm.nih.gov/pubmed/31341109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129398
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