Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity

Retinopathy of prematurity (ROP) causes 100,000 new cases of childhood blindness each year. ROP is initiated by oxygen supplementation necessary to prevent neonatal death. We used organ systems pharmacology to define the transcriptomes of mice that were cured of oxygen-induced retinopathy (OIR, ROP...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hoppe, George, Yoon, Suzy, Gopalan, Banu, Savage, Alexandria R., Brown, Rebecca, Case, Kelsey, Vasanji, Amit, Chan, E. Ricky, Silver, Randi B., Sears, Jonathan E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983815/
https://ncbi.nlm.nih.gov/pubmed/27091985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523005113
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