High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps at sub-5-kb resolution allow identification of individual DNA loops, domain organization, and large...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Johnston, Michael J., Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M.G., Seaman, Steven, Zemp, Franz J., Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M., Coutinho, Fiona J., Ma, Yussanne, Mungall, Andrew J., Moore, Richard, Marra, Marco A., Taylor, Michael D., Dirks, Peter B., Pugh, Trevor J., Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J., Lupien, Mathieu, Gallo, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673710/
https://ncbi.nlm.nih.gov/pubmed/31249064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.246520.118
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