High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps at sub-5-kb resolution allow identification of individual DNA loops, domain organization, and large...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genome Res
Päätekijät: Johnston, Michael J., Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M.G., Seaman, Steven, Zemp, Franz J., Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M., Coutinho, Fiona J., Ma, Yussanne, Mungall, Andrew J., Moore, Richard, Marra, Marco A., Taylor, Michael D., Dirks, Peter B., Pugh, Trevor J., Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J., Lupien, Mathieu, Gallo, Marco
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673710/
https://ncbi.nlm.nih.gov/pubmed/31249064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.246520.118
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia