Intratumoral genetic and functional heterogeneity in pediatric glioblastoma

Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand mechanisms of tumor evolution in this cancer, we performed whole genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Hoffman, Mary, Gillmor, Aaron H, Kunz, Daniel J, Johnston, Michael, Nikolic, Ana, Narta, Kiran, Zarrei, Mehdi, King, Jennifer, Ellestad, Katrina, Dang, Ngoc Ha, Cavalli, Florence MG, Kushida, Michelle M, Coutinho, Fiona J, Luu, Betty, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Pugh, Trevor J, Dirks, Peter B, Scherer, Stephen, Senger, Donna L, Simons, Benjamin D, Chan, Jennifer A, Morrissy, A Sorana, Gallo, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282886/
https://ncbi.nlm.nih.gov/pubmed/30877103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3441
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