High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps at sub-5-kb resolution allow identification of individual DNA loops, domain organization, and large...

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Vydáno v:Genome Res
Hlavní autoři: Johnston, Michael J., Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M.G., Seaman, Steven, Zemp, Franz J., Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M., Coutinho, Fiona J., Ma, Yussanne, Mungall, Andrew J., Moore, Richard, Marra, Marco A., Taylor, Michael D., Dirks, Peter B., Pugh, Trevor J., Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J., Lupien, Mathieu, Gallo, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673710/
https://ncbi.nlm.nih.gov/pubmed/31249064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.246520.118
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