Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling

The role of presenilin-1 (PS1) in neuronal phosphatidylinositol 3-kinase (PI3K)/Akt signaling was investigated in primary neuronal cultures from wild-type (WT) and PS1 null (PS1−/−) embryonic mouse brains. Here we show that in PS1−/− cultures, the onset of neuronal maturation coincides with a decrea...

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Publicat a:J Neurosci
Autors principals: Baki, Lia, Neve, Rachael L., Shao, Zhiping, Shioi, Junichi, Georgakopoulos, Anastasios, Robakis, Nikolaos K
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670519/
https://ncbi.nlm.nih.gov/pubmed/18184791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4067-07.2008
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