Overexpression in Neurons of Human Presenilin-1 or a Presenilin-1 Familial Alzheimer Disease Mutant Does Not Enhance Apoptosis

Programmed cell death, or apoptosis, has been implicated in Alzheimer’s disease (AD). DNA damage was assessed in primary cortical neurons infected with herpes simplex virus (HSV) vectors expressing the familial Alzheimer’s disease (FAD) gene presenilin-1 (PS-1) or an FAD mutant of this gene, A246E....

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bursztajn, Sherry, DeSouza, Richard, McPhie, Donna L., Berman, S. A., Shioi, Junichi, Robakis, Nikolaos K., Neve, Rachael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793279/
https://ncbi.nlm.nih.gov/pubmed/9822738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-23-09790.1998
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