APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1

BACKGROUND: The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds to APP-BP1, but the biological consequen...

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Autores principales: Chen, Yuzhi, Bodles, Angela M, McPhie, Donna L, Neve, Rachael L, Mrak, Robert E, Griffin, W Sue T
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802080/
https://ncbi.nlm.nih.gov/pubmed/17286867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-3
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