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APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1
BACKGROUND: The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds to APP-BP1, but the biological consequen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1802080/ https://ncbi.nlm.nih.gov/pubmed/17286867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-3 |
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