Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational ca...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Davuluri, Gangarao, Giusto, Michela, Chandel, Rajeev, Welch, Nicole, Alsabbagh, Khaled, Kant, Sashi, Kumar, Avinash, Kim, Adam, Gangadhariah, Mahesha, Ghosh, Prabar K., Tran, Uyen, Krajcik, Daniel M., Vasu, Kommireddy, DiDonato, Anthony J., DiDonato, Joseph A., Willard, Belinda, Monga, Satdarshan P., Wang, Yuxin, Fox, Paul L., Stark, George R., Wessely, Oliver, Esser, Karyn A., Dasarathy, Srinivasan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664607/
https://ncbi.nlm.nih.gov/pubmed/31138664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00451-18
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