Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations

Ethanol causes dysregulated muscle protein homeostasis while simultaneously causing hepatocyte injury. Because hepatocytes are the primary site for physiological disposal of ammonia, a cytotoxic cellular metabolite generated during a number of metabolic processes, we determined whether hyperammonemi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kant, Sashi, Davuluri, Gangarao, Alchirazi, Khaled A., Welch, Nicole, Heit, Claire, Kumar, Avinash, Gangadhariah, Mahesha, Kim, Adam, McMullen, Megan R., Willard, Belinda, Luse, Donal S., Nagy, Laura E., Vasiliou, Vasilis, Marini, Anna Maria, Weiner, I. David, Dasarathy, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509515/
https://ncbi.nlm.nih.gov/pubmed/30872403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005411
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