Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational ca...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Davuluri, Gangarao, Giusto, Michela, Chandel, Rajeev, Welch, Nicole, Alsabbagh, Khaled, Kant, Sashi, Kumar, Avinash, Kim, Adam, Gangadhariah, Mahesha, Ghosh, Prabar K., Tran, Uyen, Krajcik, Daniel M., Vasu, Kommireddy, DiDonato, Anthony J., DiDonato, Joseph A., Willard, Belinda, Monga, Satdarshan P., Wang, Yuxin, Fox, Paul L., Stark, George R., Wessely, Oliver, Esser, Karyn A., Dasarathy, Srinivasan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664607/
https://ncbi.nlm.nih.gov/pubmed/31138664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00451-18
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