Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational ca...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Davuluri, Gangarao, Giusto, Michela, Chandel, Rajeev, Welch, Nicole, Alsabbagh, Khaled, Kant, Sashi, Kumar, Avinash, Kim, Adam, Gangadhariah, Mahesha, Ghosh, Prabar K., Tran, Uyen, Krajcik, Daniel M., Vasu, Kommireddy, DiDonato, Anthony J., DiDonato, Joseph A., Willard, Belinda, Monga, Satdarshan P., Wang, Yuxin, Fox, Paul L., Stark, George R., Wessely, Oliver, Esser, Karyn A., Dasarathy, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664607/
https://ncbi.nlm.nih.gov/pubmed/31138664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00451-18
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