Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy

Protein synthesis and autophagy are regulated by cellular ATP content. We tested the hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species (ROS), contributes to impaired protein synthesis and increased proteolysis resulting in tissue atrophy in a comprehensive ar...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Kumar, Avinash, Davuluri, Gangarao, Welch, Nicole, Kim, Adam, Gangadhariah, Mahesha, Allawy, Allawy, Priyadarshini, Anupama, McMullen, Megan R, Sandlers, Yana, Willard, Belinda, Hoppel, Charles L, Nagy, Laura E, Dasarathy, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910229/
https://ncbi.nlm.nih.gov/pubmed/31574345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.09.031
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