Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy

Protein synthesis and autophagy are regulated by cellular ATP content. We tested the hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species (ROS), contributes to impaired protein synthesis and increased proteolysis resulting in tissue atrophy in a comprehensive ar...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Kumar, Avinash, Davuluri, Gangarao, Welch, Nicole, Kim, Adam, Gangadhariah, Mahesha, Allawy, Allawy, Priyadarshini, Anupama, McMullen, Megan R, Sandlers, Yana, Willard, Belinda, Hoppel, Charles L, Nagy, Laura E, Dasarathy, Srinivasan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910229/
https://ncbi.nlm.nih.gov/pubmed/31574345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.09.031
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