Hyperammonaemia‐induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress

KEY POINTS: Hyperammonaemia occurs in hepatic, cardiac and pulmonary diseases with increased muscle concentration of ammonia. We found that ammonia results in reduced skeletal muscle mitochondrial respiration, electron transport chain complex I dysfunction, as well as lower NAD(+)/NADH ratio and ATP...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Davuluri, Gangarao, Allawy, Allawy, Thapaliya, Samjhana, Rennison, Julie H., Singh, Dharmvir, Kumar, Avinash, Sandlers, Yana, Van Wagoner, David R., Flask, Chris A., Hoppel, Charles, Kasumov, Takhar, Dasarathy, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Muscle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157075/
https://ncbi.nlm.nih.gov/pubmed/27558544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272796
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