Metabolic and molecular responses to leucine enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

BACKGROUND: Skeletal muscle loss (sarcopenia) is a major clinical complication in alcoholic cirrhosis with no effective therapy. Skeletal muscle autophagic proteolysis and myostatin expression (inhibitor of protein synthesis) are increased in cirrhosis and believed to contribute to anabolic resistan...

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Bibliografske podrobnosti
izdano v:Hepatology
Main Authors: Tsien, Cynthia, Davuluri, Gangarao, Singh, Dharmvir, Allawy, Allawy, Ten Have, Gabriella AM, Thapaliya, Samjhana, Schulze, John M, Barnes, David, McCullough, Arthur J, Engelen, Marielle P.K.J., Deutz, Nicolaas E.P., Dasarathy, Srinivasan
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441611/
https://ncbi.nlm.nih.gov/pubmed/25613922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27717
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