Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of L-leucine in cirrhosis

BACKGROUND AND AIMS: Increased skeletal muscle ammonia uptake with loss of muscle mass adversely affects clinical outcomes in cirrhosis. Hyperammonemia causes reduced protein synthesis and sarcopenia but the cellular responses to impaired proteostasis and molecular mechanism of L-leucine induced ada...

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Publicado en:J Hepatol
Autores principales: Davuluri, Gangarao, Krokowski, Dawid, Guan, Bo-Jhih, Kumar, Avinash, Thapaliya, Samjhana, Singh, Dharmvir, Hatzoglou, Maria, Dasarathy, Srinivasan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069194/
https://ncbi.nlm.nih.gov/pubmed/27318325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.06.004
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