Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational ca...

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Foilsithe in:Mol Cell Biol
Main Authors: Davuluri, Gangarao, Giusto, Michela, Chandel, Rajeev, Welch, Nicole, Alsabbagh, Khaled, Kant, Sashi, Kumar, Avinash, Kim, Adam, Gangadhariah, Mahesha, Ghosh, Prabar K., Tran, Uyen, Krajcik, Daniel M., Vasu, Kommireddy, DiDonato, Anthony J., DiDonato, Joseph A., Willard, Belinda, Monga, Satdarshan P., Wang, Yuxin, Fox, Paul L., Stark, George R., Wessely, Oliver, Esser, Karyn A., Dasarathy, Srinivasan
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664607/
https://ncbi.nlm.nih.gov/pubmed/31138664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00451-18
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