Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations

Ethanol causes dysregulated muscle protein homeostasis while simultaneously causing hepatocyte injury. Because hepatocytes are the primary site for physiological disposal of ammonia, a cytotoxic cellular metabolite generated during a number of metabolic processes, we determined whether hyperammonemi...

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Udgivet i:J Biol Chem
Main Authors: Kant, Sashi, Davuluri, Gangarao, Alchirazi, Khaled A., Welch, Nicole, Heit, Claire, Kumar, Avinash, Gangadhariah, Mahesha, Kim, Adam, McMullen, Megan R., Willard, Belinda, Luse, Donal S., Nagy, Laura E., Vasiliou, Vasilis, Marini, Anna Maria, Weiner, I. David, Dasarathy, Srinivasan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509515/
https://ncbi.nlm.nih.gov/pubmed/30872403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005411
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