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Engineering proteins for allosteric control by light or ligands

Control of protein activity in living cells can reveal the role of spatio-temporal dynamics in signaling circuits. Protein analogs with engineered allosteric responses can be particularly effective, as they can replace endogenous proteins with minimum perturbation of native interactions. However, it...

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Publicat a:Nat Protoc
Autors principals: Dagliyan, Onur, Dokholyan, Nikolay V., Hahn, Klaus M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648709/
https://ncbi.nlm.nih.gov/pubmed/31076662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0165-3
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