Cell-specific CRISPR–Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

The rapid development of CRISPR–Cas technologies brought a personalized and targeted treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise and safe, strategies to confine the activity of Cas(9) to selected cells and tissues are highly desired. Here, we developed...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Hoffmann, Mareike D, Aschenbrenner, Sabine, Grosse, Stefanie, Rapti, Kleopatra, Domenger, Claire, Fakhiri, Julia, Mastel, Manuel, Börner, Kathleen, Eils, Roland, Grimm, Dirk, Niopek, Dominik
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648350/
https://ncbi.nlm.nih.gov/pubmed/30982889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz271
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