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Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity
The limited target specificity of CRISPR-Cas nucleases poses a challenge with respect to their application in research and therapy. Here, we present a simple and original strategy to enhance the specificity of CRISPR-Cas9 genome editing by coupling Cas9 to artificial inhibitory domains. Applying a c...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002122/ https://ncbi.nlm.nih.gov/pubmed/32076642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay0187 |
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