The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

по Grimm, Dirk
Опубликовано 2011

All for One, One for All: New Combinatorial RNAi Therapies Combat Hepatitis C Virus Evolution

по Grimm, Dirk
Опубликовано 2012

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal—Tailored Acceleration of AAV Evolution

по Grimm, Dirk, Zolotukhin, Sergei
Опубликовано в: Mol Ther (2015)

Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR–Cas gene editing

по Meng, Ning, Grimm, Dirk
Опубликовано в: Signal Transduct Target Ther (2021)

Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

по Grimm, Dirk, Kay, Mark A.
Опубликовано 2007

Combinatorial RNAi: A Winning Strategy for the Race Against Evolving Targets?

по Grimm, Dirk, Kay, Mark A
Опубликовано в: Mol Ther (2007)

Everybody wins! Poland hosts thrilling competitions of viruses, RNAi and football teams

по Grimm, Dirk, Dalmay, Tamas, van Rij, Ronald P
Опубликовано 2012

DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids

по King, Jason A., Dubielzig, Ralf, Grimm, Dirk, Kleinschmidt, Jürgen A.
Опубликовано 2001

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

по Mockenhaupt, Stefan, Grosse, Stefanie, Rupp, Daniel, Bartenschlager, Ralf, Grimm, Dirk
Опубликовано в: Proc Natl Acad Sci U S A (2015)

Liver Transduction with Recombinant Adeno-Associated Virus Is Primarily Restricted by Capsid Serotype Not Vector Genotype

по Grimm, Dirk, Pandey, Kusum, Nakai, Hiroyuki, Storm, Theresa A., Kay, Mark A.
Опубликовано 2006

The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9

по Akache, Bassel, Grimm, Dirk, Pandey, Kusum, Yant, Stephen R., Xu, Hui, Kay, Mark A.
Опубликовано 2006

Expression determinants of mammalian argonaute proteins in mediating gene silencing

по Valdmanis, Paul N., Gu, Shuo, Schüermann, Nina, Sethupathy, Praveen, Grimm, Dirk, Kay, Mark A.
Опубликовано 2012

Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling

по Kienle, Eike, Senís, Elena, Börner, Kathleen, Niopek, Dominik, Wiedtke, Ellen, Grosse, Stefanie, Grimm, Dirk
Опубликовано 2012

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

по Grimm, Dirk, Lee, Joyce S., Wang, Lora, Desai, Tushar, Akache, Bassel, Storm, Theresa A., Kay, Mark A.
Опубликовано 2008

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

по Gu, Shuo, Jin, Lan, Zhang, Feijie, Huang, Yong, Grimm, Dirk, Rossi, John J., Kay, Mark A.
Опубликовано 2011

Type I Interferon Regulates the Expression of Long Non-Coding RNAs

по Carnero, Elena, Barriocanal, Marina, Segura, Victor, Guruceaga, Elizabeth, Prior, Celia, Börner, Kathleen, Grimm, Dirk, Fortes, Puri
Опубликовано в: Front Immunol (2014)

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

по Singer, Mirko, Marshall, Jennifer, Heiss, Kirsten, Mair, Gunnar R., Grimm, Dirk, Mueller, Ann-Kristin, Frischknecht, Friedrich
Опубликовано в: Genome Biol (2015)

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

по Grimm, Dirk, Wang, Lora, Lee, Joyce S., Schürmann, Nina, Gu, Shuo, Börner, Kathleen, Storm, Theresa A., Kay, Mark A.
Опубликовано 2010

A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 and 8

по Akache, Bassel, Grimm, Dirk, Shen, Xuan, Fuess, Sally, Yant, Stephen R, Glazer, Dariya S, Park, Julie, Kay, Mark A
Опубликовано в: Mol Ther (2007)

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

по Malato, Yann, Naqvi, Syed, Schürmann, Nina, Ng, Raymond, Wang, Bruce, Zape, Joan, Kay, Mark A., Grimm, Dirk, Willenbring, Holger
Опубликовано 2011