Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

BACKGROUND: Genome editing of malaria parasites is key to the generation of live attenuated parasites used in experimental vaccination approaches. DNA repair in Plasmodium generally occurs only through homologous recombination. This has been used to generate transgenic parasites that lack one to thr...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Singer, Mirko, Marshall, Jennifer, Heiss, Kirsten, Mair, Gunnar R., Grimm, Dirk, Mueller, Ann-Kristin, Frischknecht, Friedrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647826/
https://ncbi.nlm.nih.gov/pubmed/26573820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0811-1
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