Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

BACKGROUND: Genome editing of malaria parasites is key to the generation of live attenuated parasites used in experimental vaccination approaches. DNA repair in Plasmodium generally occurs only through homologous recombination. This has been used to generate transgenic parasites that lack one to thr...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Singer, Mirko, Marshall, Jennifer, Heiss, Kirsten, Mair, Gunnar R., Grimm, Dirk, Mueller, Ann-Kristin, Frischknecht, Friedrich
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647826/
https://ncbi.nlm.nih.gov/pubmed/26573820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0811-1
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