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Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells

Zinc-finger nucleases are chimeric proteins consisting of engineered zinc-finger DNA-binding motifs attached to an endonuclease domain. These proteins can induce site-specific DNA double-strand breaks in genomic DNA, which are then substrates for cellular repair mechanisms. Here, we demonstrate that...

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Detaylı Bibliyografya
Asıl Yazarlar: Morton, Jason, Davis, M. Wayne, Jorgensen, Erik M., Carroll, Dana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637589/
https://ncbi.nlm.nih.gov/pubmed/17060623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605633103
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