Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

Mitochondrial DNA (mtDNA) deletions are associated with various mitochondrial disorders. The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated. In contrast to nuclear DNA (nDN...

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Udgivet i:Mol Biol Cell
Main Authors: Tadi, Satish Kumar, Sebastian, Robin, Dahal, Sumedha, Babu, Ravi K., Choudhary, Bibha, Raghavan, Sathees C.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713127/
https://ncbi.nlm.nih.gov/pubmed/26609070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0260
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