Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

MicroRNAs and siRNAs interact with target sequences in mRNAs, inducing cleavage- and non-cleavage–based gene repression through the RNA-induced silencing complex (RISC) that consists of one of four mammalian Argonaute proteins, Ago1–Ago4. The process of how Dicer substrate small hairpin RNAs (shRNAs...

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Detaylı Bibliyografya
Asıl Yazarlar: Gu, Shuo, Jin, Lan, Zhang, Feijie, Huang, Yong, Grimm, Dirk, Rossi, John J., Kay, Mark A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107324/
https://ncbi.nlm.nih.gov/pubmed/21576459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018023108
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