A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs

In humans a single species of the RNAseIII enzyme Dicer processes both microRNA precursors into miRNAs and long double-stranded RNAs into small interfering RNAs (siRNAs). An interesting but poorly understood domain of the mammalian Dicer protein is the N-terminal helicase-like domain that possesses...

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Bibliographic Details
Main Authors: Soifer, Harris S., Sano, Masayuki, Sakurai, Kumi, Chomchan, Pritsana, Sætrom, Pål, Sherman, Mark A., Collingwood, Michael A., Behlke, Mark A., Rossi, John J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582626/
https://ncbi.nlm.nih.gov/pubmed/18927112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn687
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