Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs

Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and show improved potency as triggers of RNA interference, particularly when used at low dose. Chemical modification patterns that are compatible with high potency 21-mer small...

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Detalhes bibliográficos
Main Authors: Collingwood, Michael A., Rose, Scott D., Huang, Lingyan, Hillier, Chris, Amarzguioui, Mohammad, Wiiger, Merete T., Soifer, Harris S., Rossi, John J., Behlke, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582043/
https://ncbi.nlm.nih.gov/pubmed/18637735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/oli.2008.0123
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