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The Drosophila Dicer-1 partner Loquacious enhances miRNA processing from hairpins with unstable structures at the dicing site

In Drosophila, Dicer-1 binds Loquacious-PB (Loqs-PB) as its major co-factor. Previous analyses indicated that loqs mutants only partially impede miRNA processing but the activity of minor isoforms or maternally deposited Loqs was not eliminated in these studies. We addressed this by generating a cel...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Lim, Mandy Yu Theng, Ng, Alvin Wei Tian, Chou, Yuting, Lim, Teck Por, Simcox, Amanda, Tucker-Kellogg, Greg, Okamura, Katsutomo
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880499/
https://ncbi.nlm.nih.gov/pubmed/27184838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.059
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