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Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes
MicroRNAs and siRNAs interact with target sequences in mRNAs, inducing cleavage- and non-cleavage–based gene repression through the RNA-induced silencing complex (RISC) that consists of one of four mammalian Argonaute proteins, Ago1–Ago4. The process of how Dicer substrate small hairpin RNAs (shRNAs...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107324/ https://ncbi.nlm.nih.gov/pubmed/21576459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018023108 |
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