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Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
shRNA overexpression from viral gene therapy vectors can trigger cytotoxicity leading to organ failure and lethality in mice and rats. This process likely involves saturation of endogenous cellular RNAi factors including exportin-5 (Xpo-5). Here, we have shown that Xpo-5 overexpression enhanced shRN...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929739/ https://ncbi.nlm.nih.gov/pubmed/20697157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43565 |
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