Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

As the only mammalian Argonaute protein capable of directly cleaving mRNAs in a small RNA-guided manner, Argonaute-2 (Ago2) is a keyplayer in RNA interference (RNAi) silencing via small interfering (si) or short hairpin (sh) RNAs. It is also a rate-limiting factor whose saturation by si/shRNAs limit...

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Main Authors: Börner, Kathleen, Niopek, Dominik, Cotugno, Gabriella, Kaldenbach, Michaela, Pankert, Teresa, Willemsen, Joschka, Zhang, Xian, Schürmann, Nina, Mockenhaupt, Stefan, Serva, Andrius, Hiet, Marie-Sophie, Wiedtke, Ellen, Castoldi, Mirco, Starkuviene, Vytaute, Erfle, Holger, Gilbert, Daniel F., Bartenschlager, Ralf, Boutros, Michael, Binder, Marco, Streetz, Konrad, Kräusslich, Hans-Georg, Grimm, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834839/
https://ncbi.nlm.nih.gov/pubmed/24049077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt836
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