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Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling

Adeno-associated viral (AAV) vectors represent some of the most potent and promising vehicles for therapeutic human gene transfer due to a unique combination of beneficial properties(1). These include the apathogenicity of the underlying wildtype viruses and the highly advanced methodologies for pro...

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Detalhes bibliográficos
Main Authors: Kienle, Eike, Senís, Elena, Börner, Kathleen, Niopek, Dominik, Wiedtke, Ellen, Grosse, Stefanie, Grimm, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460542/
https://ncbi.nlm.nih.gov/pubmed/22491297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3819
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