In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Liver fibrosis, a form of scarring, gradually develops in chronic liver diseases when hepatocyte regeneration cannot compensate for hepatocyte death. At earlier stages, collagen produced by activated myofibroblasts (MFs) functions to maintain tissue integrity, but upon repeated injury, collagen accu...

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Pubblicato in:Cell Stem Cell
Autori principali: Rezvani, Milad, Español-Suñer, Regina, Malato, Yann, Dumont, Laure, Grimm, Andrew A., Kienle, Eike, Bindman, Jay G., Wiedtke, Ellen, Hsu, Bernadette Y., Naqvi, Syed J., Schwabe, Robert F., Corvera, Carlos U., Grimm, Dirk, Willenbring, Holger
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325707/
https://ncbi.nlm.nih.gov/pubmed/27257763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.05.005
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