In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Liver fibrosis, a form of scarring, gradually develops in chronic liver diseases when hepatocyte regeneration cannot compensate for hepatocyte death. At earlier stages, collagen produced by activated myofibroblasts (MFs) functions to maintain tissue integrity, but upon repeated injury, collagen accu...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Rezvani, Milad, Español-Suñer, Regina, Malato, Yann, Dumont, Laure, Grimm, Andrew A., Kienle, Eike, Bindman, Jay G., Wiedtke, Ellen, Hsu, Bernadette Y., Naqvi, Syed J., Schwabe, Robert F., Corvera, Carlos U., Grimm, Dirk, Willenbring, Holger
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325707/
https://ncbi.nlm.nih.gov/pubmed/27257763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.05.005
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