In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Liver fibrosis, a form of scarring, gradually develops in chronic liver diseases when hepatocyte regeneration cannot compensate for hepatocyte death. At earlier stages, collagen produced by activated myofibroblasts (MFs) functions to maintain tissue integrity, but upon repeated injury, collagen accu...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Rezvani, Milad, Español-Suñer, Regina, Malato, Yann, Dumont, Laure, Grimm, Andrew A., Kienle, Eike, Bindman, Jay G., Wiedtke, Ellen, Hsu, Bernadette Y., Naqvi, Syed J., Schwabe, Robert F., Corvera, Carlos U., Grimm, Dirk, Willenbring, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325707/
https://ncbi.nlm.nih.gov/pubmed/27257763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.05.005
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