AAV vector-mediated in vivo reprogramming into pluripotency

In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4, Klf4, Sox2, c-Myc; OKSM) in selected organs. Here, we rep...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Senís, Elena, Mosteiro, Lluc, Wilkening, Stefan, Wiedtke, Ellen, Nowrouzi, Ali, Afzal, Saira, Fronza, Raffaele, Landerer, Henrik, Abad, Maria, Niopek, Dominik, Schmidt, Manfred, Serrano, Manuel, Grimm, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037684/
https://ncbi.nlm.nih.gov/pubmed/29985406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05059-x
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