Physiological Ranges of Matrix Rigidity Modulate Primary Mouse Hepatocyte Function In Part Through Hepatocyte Nuclear Factor 4 Alpha

Matrix rigidity has important effects on cell behavior and is increased during liver fibrosis; however, its effect on primary hepatocyte function is unknown. We hypothesized that increased matrix rigidity in fibrotic livers would activate mechanotransduction in hepatocytes and lead to inhibition of...

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Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Desai, Seema S., Tung, Jason C., Zhou, Vivian X., Grenert, James P., Malato, Yann, Rezvani, Milad, Español-Suñer, Regina, Willenbring, Holger, Weaver, Valerie M., Chang, Tammy T.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224931/
https://ncbi.nlm.nih.gov/pubmed/26755329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28450
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