Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors

Transitioning to human trials from pre-clinical models resulted in the emergence of inhibitory AAV vector immune responses which has become a hurdle for sustained correction. Early animal studies did not predict the full range of host immunity to the AAV vector in human studies. While pre-existing a...

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Bibliographic Details
Main Authors: Basner-Tschakarjan, Etiena, Bijjiga, Enoch, Martino, Ashley T.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916775/
https://ncbi.nlm.nih.gov/pubmed/24570676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00028
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