Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant lesions. Since...

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Publicado no:Cancer Discov
Main Authors: Carrer, Alessandro, Trefely, Sophie, Zhao, Steven, Campbell, Sydney L., Norgard, Robert J., Schulz, Kollin C., Sidoli, Simone, Parris, Joshua L. D., Affronti, Hayley C., Sivanand, Sharanya, Egolf, Shaun, Sela, Yogev, Trizzino, Marco, Gardini, Alessandro, Garcia, Benjamin A., Snyder, Nathaniel W., Stanger, Ben Z., Wellen, Kathryn E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643997/
https://ncbi.nlm.nih.gov/pubmed/30626590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0567
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