Nuclear acetyl-CoA production by ACLY promotes homologous recombination

While maintaining the integrity of the genome and sustaining bioenergetics are both fundamental functions of the cell, potential crosstalk between metabolic and DNA repair pathways is poorly understood. Since histone acetylation plays important roles in DNA repair and is sensitive to the availabilit...

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Udgivet i:Mol Cell
Main Authors: Sivanand, Sharanya, Rhoades, Seth, Jiang, Qinqin, Lee, Joyce V., Benci, Joseph, Zhang, Jingwen, Yuan, Salina, Viney, Isabella, Zhao, Steven, Carrer, Alessandro, Bennett, Michael J., Minn, Andy J, Weljie, Aalim M, Greenberg, Roger A., Wellen, Kathryn E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580398/
https://ncbi.nlm.nih.gov/pubmed/28689661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.008
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