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Spatiotemporal control of acetyl-CoA metabolism in chromatin regulation

The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specificity in gene regulation is achieved by a metabolite has been...

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Bibliographic Details
Published in:Trends Biochem Sci
Main Authors: Sivanand, Sharanya, Viney, Isabella, Wellen, Kathryn E.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741483/
https://ncbi.nlm.nih.gov/pubmed/29174173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2017.11.004
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