Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant lesions. Since...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Carrer, Alessandro, Trefely, Sophie, Zhao, Steven, Campbell, Sydney L., Norgard, Robert J., Schulz, Kollin C., Sidoli, Simone, Parris, Joshua L. D., Affronti, Hayley C., Sivanand, Sharanya, Egolf, Shaun, Sela, Yogev, Trizzino, Marco, Gardini, Alessandro, Garcia, Benjamin A., Snyder, Nathaniel W., Stanger, Ben Z., Wellen, Kathryn E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643997/
https://ncbi.nlm.nih.gov/pubmed/30626590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0567
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