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Phenotypic screening combined with machine learning for efficient identification of breast cancer-selective therapeutic targets

The lack of functional understanding of most mutations in cancer, combined with the nondruggability of most proteins, challenge genomics-based identification of oncology drug targets. We implemented a machine learning-based approach (idTRAX), which relates cell-based screening of small-molecule comp...

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發表在:Cell Chem Biol
Main Authors: Gautam, Prson, Jaiswal, Alok, Aittokallio, Tero, Al-Ali, Hassan, Wennerberg, Krister
格式: Artigo
語言:Inglês
出版: 2019
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642004/
https://ncbi.nlm.nih.gov/pubmed/31056464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.011
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