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Prediction of drug combination effects with a minimal set of experiments

High-throughput drug combination screening provides a systematic strategy to discover unexpected combinatorial synergies in pre-clinical cell models. However, phenotypic combinatorial screening with multi-dose matrix assays is experimentally expensive, especially when the aim is to identify selectiv...

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Detalhes bibliográficos
Publicado no:Nat Mach Intell
Main Authors: Ianevski, Aleksandr, Giri, Anil K, Gautam, Prson, Kononov, Alexander, Potdar, Swapnil, Saarela, Jani, Wennerberg, Krister, Aittokallio, Tero
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198051/
https://ncbi.nlm.nih.gov/pubmed/32368721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42256-019-0122-4
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