Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

BACKGROUND: Genome-wide loss-of-function profiling is widely used for systematic identification of genetic dependencies in cancer cells; however, the poor reproducibility of RNA interference (RNAi) screens has been a major concern due to frequent off-target effects. Currently, a detailed understandi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Genome Med
Hlavní autoři: Jaiswal, Alok, Peddinti, Gopal, Akimov, Yevhen, Wennerberg, Krister, Kuznetsov, Sergey, Tang, Jing, Aittokallio, Tero
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452371/
https://ncbi.nlm.nih.gov/pubmed/28569207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0440-2
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky