Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

BACKGROUND: Genome-wide loss-of-function profiling is widely used for systematic identification of genetic dependencies in cancer cells; however, the poor reproducibility of RNA interference (RNAi) screens has been a major concern due to frequent off-target effects. Currently, a detailed understandi...

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Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Jaiswal, Alok, Peddinti, Gopal, Akimov, Yevhen, Wennerberg, Krister, Kuznetsov, Sergey, Tang, Jing, Aittokallio, Tero
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452371/
https://ncbi.nlm.nih.gov/pubmed/28569207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0440-2
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