From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Kryukova, Elena V., Egorova, Natalia S., Kudryavtsev, Denis S., Lebedev, Dmitry S., Spirova, Ekaterina N., Zhmak, Maxim N., Garifulina, Aleksandra I., Kasheverov, Igor E., Utkin, Yuri N., Tsetlin, Victor I.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6616073/
https://ncbi.nlm.nih.gov/pubmed/31333465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00748
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