Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models

Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three β-structural loops, similarly to snake venom α-neurotoxin TFPs. Since the central loop II of α-neurotoxins is involved in binding...

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Udgivet i:Biomolecules
Main Authors: Mineev, Konstantin S., Kryukova, Elena V., Kasheverov, Igor E., Egorova, Natalia S., Zhmak, Maxim N., Ivanov, Igor A., Senko, Dmitry A., Feofanov, Alexey V., Ignatova, Anastasia A., Arseniev, Alexander S., Utkin, Yuri N., Tsetlin, Victor I.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821949/
https://ncbi.nlm.nih.gov/pubmed/33374963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11010001
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