Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Mitochondrial complex I dysfunction is the most common respiratory chain defect in human disorders and a hotspot for neurodegenerative diseases. Amyloid precursor protein (APP) and its non-amyloidogenic processing products, in particular soluble APP α (sAPPα), have been shown to provide neuroprotect...

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Vydáno v:Mol Neurobiol
Hlavní autoři: Cimdins, Kathryn, Waugh, Hayley S., Chrysostomou, Vicki, Lopez Sanchez, M. Isabel G., Johannsen, Vanessa A., Cook, Mark J., Crowston, Jonathan G., Hill, Andrew F., Duce, James A., Bush, Ashley I., Trounce, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614131/
https://ncbi.nlm.nih.gov/pubmed/30612335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1460-7
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